Summaries by Inventor Murphy, Kenneth
Murphy, Kenneth ; Murphy, Theresa ; Watanabe, Norihiko ; Yang, Jianfei
T-004061
— Background: B and T lymphocyte attenuator (BTLA or CD272) is an inhibitory receptor expressed on T and B cells, dendritic cells and select myeloid cells. BTLA interacts with costimulatory molecule herpesvirus entry mediator (HVEM, Tnfrsf14, ATAR, HVEA, LIGHTR, or TR2). When bound to BTLA, HVEM atten…
Hamster Hybridoma producing Monoclonal Antibody against Murine CD272 (BTLA)Hurchla, Michelle ; Murphy, Kenneth ; Murphy, Theresa ; Sedy, John
T-004458
— Target: B and T lymphocyte attenuator (BTLA). BTLA is expressed on peripheral lymphocytes, splenic macrophages and select developing B and T cells.Inventors created the monoclonal antibodies by immunizing Armenian hamster or BALB/c background BTLA -/- mice. Hamster monoclonal 6A6 is of the IgG isotype, whereas all murine Abs are IgG1κ. Some of the antibodies recognize the mouse BTLA C57/BL6 allele (6A6, 3F9.C6) and some are panspecific (…
IRF8 +32 KO miceMurphy, Kenneth
T-018830
— Researchers first identified and then used CRISPR to delete an enhancer located at +32 kb of the Irf8 transcriptional start site in mice. Knocking out this enhancer revealed that interferon regulatory factor 8 (IRF8) is required for the development of classical type 1 dendritic cells (cDC1s) but not…
Irf8 Delta32 MiceMurphy, Kenneth
T-019003
— Irf8 Delta32 mice have a CRISPR targetted deletion in the enhancer of the mouse Irf8 gene located at +32 kilobases from the Irf8 gene promoter. This deletion removes the binding site for the Jun/Batf3/Irf8 complex and results in a complete and permanent elimination of the development of the cDC1 lin…
Xcr1 IRES mCherry-hCre Mouse StrainDurai, Vivek ; Murphy, Kenneth ; Murphy, Theresa
T-019142
— Xcr1 IRES mCherry-hCre Mouse Strain This genetically modified mouse strain expresses the fluorescent marker mCherry and a human codon optimzed Cre in the same transcript as the chemokine receptor XCR1. XCR1 is specifically expressed in cDC1s, allowing specific deletion of genes in and the fluoresce…
B6.129.Btla tm1kmm/J MouseMurphy, Kenneth ; Murphy, Theresa
T-014100
— Notes: Btla-/- knockout mouse with a 129S/SvEv background. B6.129.Btla tm1kmm/J Mouse.
Knockout Mouse lacking Expression of the Batf3 GeneDiamond, Michael ; Murphy, Kenneth ; Murphy, Theresa ; Schreiber, Robert ; Unanue, Emil
T-009136
— Notes: Batf3-/- knockout mouse with a 129SvEv background.
Graft-vs-Host Disease Prevention during Stem Cell TransplantationAlbring, Jorn ; Murphy, Kenneth ; Sandau, Michelle
T-009478
— Background: Allogeneic hematopoietic stem-cell transplantation (aHSCT) from a healthy donor can cure a variety of blood cell disorders including leukemia, multiple myeloma, and some types of lymphoma. This has resulted in an increasing number of transplants, surpassing 8,000 a year in the US alone. …
Modulation of Lymphocyte ActivityMurphy, Kenneth ; Murphy, Theresa ; Watanabe, Norihiko ; Yang, Jianfei
T-004061
— Background: B and T lymphocyte attenuator (BTLA or CD272) is an inhibitory receptor expressed on T and B cells, dendritic cells and select myeloid cells. BTLA interacts with costimulatory molecule herpesvirus entry mediator (HVEM, Tnfrsf14, ATAR, HVEA, LIGHTR, or TR2). When bound to BTLA, HVEM atten…
